Upon pathogen infection or treatment with SA or its functional analogs 2,6-dichloroisonicotinic acid (INA) and benzothiadiazole (BTH), NPR1 translocates from the cytoplasm into the nucleus, where it interacts with the TGA2 transcription factor to promote expression of multiple PR genes (Cao et al., 1994; Delaney et al., 1995; Ryals et al., 1997; Shah et al., 1997; Mou et al., 2003). The gene discussed is NPR1; the disease is infection.