IL6R and systemic sclerosis: With regard to other immunosuppressive agents, a wide variety of treatments for SSc have been explored including azathioprine, methotrexate and, more recently, targeted therapies with monoclonal antibodies, including tocilizumab (anti-interleukin-6 receptor antibody), rituximab (an anti-CD20 antibody), and fresolimumab (an anti-TGFß antibody) (22).