Correlating to Mtb loads, when BCG primed mice were boosted with LP-ESAT-6 subunit vaccine after infection with Mtb, there were higher levels of IFN-γ, IL-17A, and IL-22 and lower levels of IL-10 compared to BCG-vaccinated mice, demonstrating the increase in protective immunity (Figure 2B). Here, IL22 is linked to infection.