While all family members had CARD14 mutations, the PRP sufferers had an additional frame-shift mutation in DTX1, a regulator of regulatory T cells, while the psoriasis-affected individual harbored a mutation in NLRC5, a molecule that activates NF-κB but also regulates MHC-I transcription (42). The gene discussed is CARD14; the disease is familial pityriasis rubra pilaris.