CYP19A1 and Alzheimer disease: Women with SNP rs1065778 GG in the CYP19 gene was associated with increased odds ratio risk of developing AD.An interaction existed in women between IL-10 rs1800896 and CYP19A1 rs1062033 and increased risk for AD.Findings suggest that decreased serum E2 and neuroE2 may increase neuro-inflammation and risk for AD.