As shown in Figure 1, this nanoplatform is composed of a classic liposome structure (i.e., one phospholipid bilayer surrounding an aqueous core), hydrophilic polyethylene glycol (PEG) chains on the outer shell, and surface-encoded aptamer-like peptide (aptide) to specifically target the EDB of fibronectin that over-expressed on glioma cells (Borsi et al., 1992; Castellani et al., 2002; Han and Lu, 2017; Saw et al., 2017). This evidence concerns the gene FN1 and central nervous system cancer.