However, recent studies have reported that the gain-of-function mutation of Nav1.6 increased trigeminal ganglia (TRG) neuron excitability in trigeminal neuralgia (Tanaka et al., 2016) while Nav1.6 knockdown ameliorated mechanical pain behavior in models of local inflammation and neuropathic pain (Xie et al., 2013, 2015). The gene discussed is SCN8A; the disease is trigeminal neuralgia.