Nav1.6, mainly distributed in the central nervous system and mature nodes of Ranvier in the peripheral nervous system (Habib et al., 2015), has been previously shown to be related with infantile epileptic encephalopathy (Veeramah et al., 2012; Estacion et al., 2014; Blanchard et al., 2015). This evidence concerns the gene SCN8A and infantile epileptic encephalopathy.