Other possible targets are Bcl-2 family components, regulators of the mitochondrial pathway of apoptosis (Popgeorgiev et al., 2018), and the promoters of caspase 8 hypermethylation in those cancer cells that have its expression suppressed, as described in some hepatocellular carcinoma mouse models (Fulda et al., 2001; Liedtke et al., 2005; Fulda, 2017). Here, CASP8 is linked to cancer.