MAPT and Neurodegeneration: Because tauopathies and cochlear neurodegeneration share the common pathophysiological correlate of oxidative stress (Alavi Naini and Soussi-Yanicostas, 2015; Du et al., 2016, 2017; Tavanai and Mohammadkhani, 2017) have demonstrated that therapeutic intervention with antioxidants significantly decreased both pathologic tau accumulation and indications of ongoing neurodegeneration in the cochlea and auditory cortex of blast-exposed rats.