TRPV1 and axonal neuropathy: TRPV1 and TRPV4 channels have been implicated in optic nerve degeneration (Križaj et al., 2014; Sappington et al., 2015) and axonal neuropathies (Echaniz-Laguna et al., 2014), and shown to be sensitive to mechanical stressors (such as changes in cell volume and strain; Sudbury et al., 2010; Ryskamp et al., 2016).