Through meta-analysis, we also observed that high Kindlin-2 expression significantly correlated with poor OS in patients with ESCC (HR 1.71, 95% CI 1.19–2.47, P = 0.004), HCC (HR 2.33, 95% CI 1.38–3.93, P = 0.002), ccRCC (HR 1.75, 95% CI 1.22–2.52, P = 0.003) (Fig. 4). The gene discussed is FERMT2; the disease is hepatocellular carcinoma.