Elevated expression level of Kindlin-2 was significantly associated with a poor prognosis in patients with PDAC (DFS/RFS/PFS), ESCC (OS, DFS/RFS/PFS), HCC (OS), ccRCC (OS), BC (OS, DFS/RFS/PFS), CHS (OS), OSS (OS), GC (DFS/RFS/PFS) and glioma (OS), but not PDAC (OS), GC (OS), sEOC (OS, DFS/RFS/PFS). The gene discussed is FERMT2; the disease is central nervous system cancer.