The pooled data also showed statistically association between high Kindlin-2 expression with poor RFS/DFS/PFS in ESCC (HR 1.59, 95% CI 1.10–2.28, P = 0.0129), HCC (HR 4.30, 95% CI 1.81–10.19), ccRCC (HR 1.47, 95% CI 1.05–2.06) (Fig. 4). Here, FERMT2 is linked to esophageal squamous cell carcinoma.