The critical role of SOX11 for human CNS development was predicted by single-cell transcriptomic analysis of human neocortical development7 and was confirmed by the discovery that heterozygote mutations in Sox11 are associated with Coffin-Siris Syndrome, a rare human congenital disorder characterized by intellectual disability, microcephaly and growth deficiency8,9. This evidence concerns the gene SOX11 and Coffin-Siris syndrome.