Similarly, in an early stage obesity rat model, a significant reduction in β-catenin levels and increased adipogenesis have been reported to be dependent on Wnt/MAPK-signaling50.We propose that intracellular Panx1 may control the differentiation and proliferative capacities of ASCs through modulation of calcium and/or other regulatory pathways such as Wnt signaling. The gene discussed is PANX1; the disease is obesity due to melanocortin 4 receptor deficiency.