Similarly, in an early stage obesity rat model, a significant reduction in β-catenin levels and increased adipogenesis have been reported to be dependent on Wnt/MAPK-signaling50.We propose that intracellular Panx1 may control the differentiation and proliferative capacities of ASCs through modulation of calcium and/or other regulatory pathways such as Wnt signaling. This evidence concerns the gene PANX1 and obesity disorder.