This finding is consistent with the previously observed suppression of ERAD in cells with NGLY1 malfunction.1,4,5,15,17–19 Since GADD153 is an important mediator for ER stress-associated apoptosis,13 our findings suggest that ER stress signalling-mediated apoptosis may contribute to the death of melanoma cells with NGLY1 suppression. Here, NGLY1 is linked to melanoma.