NGLY1 and ovarian cancer: Notably, NGLY1 appears to be highly expressed in certain human cancer cells (e.g., melanoma and ovarian cancer), while low-to-undetectable in their normal counterpart tissues (e.g., skin and ovary) (www.proteinatlas.org).10 These observations raise an intriguing possibility that NGLY1 may be crucial for cancer development and progression.