Specifically, microglia in lupus have been shown to become pathogenic in a type 1 interferon manner58, microglia sorted from Alzheimer disease amyloid precursor protein (APP)-transgenic mice demonstrated a type 1 interferon profile59 and inhibiting type 1 interferon signaling in microglia was shown to blunt age-related deficits60. Here, APP is linked to systemic lupus erythematosus.