THY1 and Parkinson disease: The effects of NPT200-11 administration (0, 0.5, 1 & 5 mg/kg) on PD-relevant neuropathological and behavioral endpoints were evaluated in three month studies utilizing a transgenic mouse model of PD overexpressing human wild type ASYN under the murine Thy-1 promoter (commonly referred to as the Line 61 ASYN transgenic mice).