Comparison of the targets showed that 191 targets belonged to SZC but not to synthetic drugs, and 35 targets belonged to synthetic drugs but not to SZC (Fig. 4A), including CXCL10 (C-X-C motif chemokine ligand 10), IL1A, RPS6KB1 (ribosomal protein S6 kinase B1), etc. Gene ontology (GO) and KEGG pathway analysis of the targets of synthetic drugs showed that they were highly related to immune response and primary immunodeficiency pathway, while the targets of SZC were related to broad functions and pathways (see below and Supplementary Figs 1 and 2). The gene discussed is IL1A; the disease is inborn error of immunity.