Knocking down BRD2 or BRD4 only moderately inhibited RCC cell proliferation, which might be due to the compensatory effect by other BET family members, while knocking down both BRD2 and BRD4 resulted in remarkable suppression of RCC cell proliferation and reduced expression of c-Myc onco-protein. The gene discussed is BRD4; the disease is renal cell carcinoma.