TLR9 and malaria: When considering biomarkers ratios, increases in TLR3-mediated IL7 response were predictive of an increased risk of clinical malaria attack, while higher TLR9-mediated eotaxin responses and TLR7/8-mediated IL-1RA and IL-12 responses had a protective effect against developing a malaria episode during the first year of life (Table 3).