CSF2 and infection: However, the trend analysis revealed a significant trend towards decreasing production among unstimulated samples from infants born to mothers with peripheral infection to those born to mothers with PM (past, chronic, and acute, respectively) for some biomarkers including IL-10 (P for trend = 0.024), IL-12 (P for trend = 0.042), and GM-CSF (P for trend = 0.032).