EPCAM and neoplasm: These EpCAM+, CK+, CD45− objects, baptized tumor-derived extracellular vesicles (tdEVs), can now be classified with objective criteria using the open-source image analysis software, Automatic CTC Classification, Enumeration and PhenoTyping (ACCEPT) (http://github.com/LeonieZ/ACCEPT), and are equivalent to CTCs in terms of prognosis of CRPC patients [19].