The cHL and GCB DLBCL samples had fewer infiltrating macrophages than non-GCB DLBCL (p < 0.0001) These observations were confirmed in the second cohort from our institution, in which cHL samples were significantly enriched in CD4+ T-cells compared to DLBCL (p < 0.05) regardless of GCB/non-GCB subtype (Figure 2B). Here, CD4 is linked to diffuse large B-cell lymphoma.