KRAS and gastric cancer: Atp4b-Cre mice crossed with mice that conditionally overexpress the intracellular domain of Notch develop intestinal-type dysplasia in the corpus, while the progeny of those crossed with Cdh1flox/flox mice, in combination with the knockout of Tp53 or mutant Kras, develop a diffuse-type gastric cancer [40,41].