Treatment with EDE1-B10 at a later time point (i.e., three days following infection) in the WT + anti-Ifnar1 model also reduced ZIKV RNA in maternal and fetal tissues, but to a lesser degree, implying that antibody-based therapeutics may need to be administered within a certain time window after infection to convey maximal benefit. The gene discussed is IFNAR1; the disease is infection.