IFNAR1 and infection: Administration of EDE1-B10 mAb to WT + anti-Ifnar1 mAb-treated mice one day after maternal infection with a mouse adapted ZIKV (Dakar strain) resulted in a markedly reduced ZIKV burden in the placenta (660,0000-fold reduction) and fetal head (4900-fold reduction), with a substantial fraction of placentas and fetal heads containing no detectable virus.