Finally, genetic analysis for hereditary thrombohilia has been suggested to be done for only women with additional thrombophilia risk factors according to the recent ESHRE guidelines on RPL, consideration of FGB-455G/A and HPA-1 rs5918 T > C polymorphisms in thrombophilia panel of RPL patients may improve diagnosis rate of those patients (https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Recurrent-pregnancy-loss). This evidence concerns the gene FGB and Rare hereditary thrombophilia.