Conversely, RNAi therapy targeting KRAS in combination with chemotherapy showed efficacy in treating locally advanced pancreatic cancer patients [40], whereas the G-protein-coupled receptor family C, member 5, group A gene was upregulated in PaCa cells, which led to enhanced drug resistance in PaCa cells [50]. Here, KRAS is linked to permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.