Recent reports showed that treatment with 25–100 μM NaHS reduced PTEN expression, whereas 800–1000 μM NaHS increased the level of PTEN protein in hepatocellular carcinoma cells [67]; however, the relative roles of H2S donor in PTEN regulation in innate immune cells are still mostly unexplored. The gene discussed is PTEN; the disease is hepatocellular carcinoma.