While several types of cancer cells undergo noticeable initial responses to cell death-inducing agents such as chemotherapeutic or radiotherapeutic approaches, these cells may nonetheless relapse even after reaching the assumed “point of no return”, such as by the MOMP-mediated activation of effector caspases such as caspase-3 activation, and ultimately, metastasis often takes place in many types of cancer [144]. This evidence concerns the gene CASP3 and cancer.