Very recently, Esposito et al. [11] have published the use of an aptamer-siRNA chimera (Gint4.T-STAT3) that binds to the oncogenic receptor platelet-derived growth factor receptor-β (PDGFRβ), Gint4.T, and specifically, target STAT3 into glioblastoma (GBM)-derived cells in a receptor-dependent manner. Here, STAT3 is linked to glioblastoma.