NR3C2 and hydrops fetalis: The European Society of Cardiology HF guidelines recommend sacubitril/valsartan as a replacement for an ACEi to further reduce the risk of HF hospitalisation and death in ambulatory patients with HF with reduced ejection fraction (EF) who remain symptomatic despite optimal treatment with an ACEi, a β-blocker, and a mineralocorticoid receptor antagonists (MRA) [65].