There was a statistically significant decrease in concentration of CCL-12 (chemokine C-C motif ligand 12) and endoglin in IP tumor ITF that was not observed in orthotopic tumor ITF samples, and a trend to decreased concentration of P-selectin in IP tumor ITF, that did reach statistical significance in the orthotopic model (Figure 5C,D). The gene discussed is ENG; the disease is incontinentia pigmenti.