For example, about 6% prostate adenoma patients demonstrated amplification of ATX in the TCGA dataset (330 patients) [48] and 5% in the MSKCC/DFCI dataset (1013 patients) [49], whereas the rate in metastatic PCa patients increased to 12% in the SU2C/PCF dataset (150 patients) [50] and 20% in the MCTP dataset (61 patients) [51]. Here, ENPP2 is linked to posterior cortical atrophy.