Comparison of normal fibroblasts and stromal cells to their tumor counterparts showed a striking upregulation of collagen genes including COL1A1, COL1A2, COL3A1, COL4A1, COL4A2 COL5A1, COL5A2, COL6A1 and COL6A3 as well as collagen support genes, SPARC, SERPINH1 and SERPINE1 (Table 4). This evidence concerns the gene SERPINE1 and neoplasm.