SPARC and neoplasm: Comparison of normal fibroblasts and stromal cells to their tumor counterparts showed a striking upregulation of collagen genes including COL1A1, COL1A2, COL3A1, COL4A1, COL4A2 COL5A1, COL5A2, COL6A1 and COL6A3 as well as collagen support genes, SPARC, SERPINH1 and SERPINE1 (Table 4).