Mutated Kras induces the expression of ICAM-1, which serves as a chemoattractant for macrophages and contributes to the formation of pancreatic intraepithelial neoplasms (PanINs), the most common precursor lesions for pancreatic ductal adenocarcinoma [24]. The gene discussed is ICAM1; the disease is pancreatic ductal adenocarcinoma.