Irrespective of bacterial burden or granuloma presence, the proliferative capacity of T cells, as measured by Ki67+ CD3+ T cells, especially Ki67+ CD8+ cytotoxic T cells (S4 Table, S6C Fig), was significantly higher in thoracic LNs than in peripheral LNs, suggesting that Mtb induced proliferation might occur in the thoracic LNs. The gene discussed is MKI67; the disease is Granuloma.