IFNG and Granuloma: Of note, LNs with granulomas that are sterile had significantly higher frequencies of CD3+ T cells producing IFNγ (Fig 8C); CD8+ cytotoxic T cells producing IFNγ, IL-2 or TNF (Fig 8D) and CD20+ B cells producing IL-2 (Fig 8E) than CFU+ LNs.