CD8A and Granuloma: Irrespective of bacterial burden or granuloma presence, the proliferative capacity of T cells, as measured by Ki67+ CD3+ T cells, especially Ki67+ CD8+ cytotoxic T cells (S4 Table, S6C Fig), was significantly higher in thoracic LNs than in peripheral LNs, suggesting that Mtb induced proliferation might occur in the thoracic LNs.