Several non-mutually exclusive mechanisms may underlie the association between T2D and dementia, but increased cerebrovascular compromise and blood-brain barrier disruption[41–43]; defective signal transduction mechanism of central nervous system insulin receptors[44, 45]; and their potential interactions with amyloidogenic processes[44, 46–48] are among the most prominent see also, [19]. This evidence concerns the gene INSR and type 2 diabetes mellitus.