While BRCA1-BARD1 has been extensively studied with respect to its crucial tumor suppressor activities, we still do not fully understand how this protein complex mediates the diverse functions that have been ascribed to it (e. g., DNA metabolism, checkpoint signaling, chromatin dynamics, centrosome amplification, and transcriptional and translational regulation [4, 5]). The gene discussed is BRCA1; the disease is neoplasm.