An animal experiments have shown that BBTD could reduce serum TC, triglyceride (TG), LDL-C, apolipoprotein B (apoB), superoxide dismutase (SOD), malondialdehyde (MDA) in rats with hyperlipidemia.[13] Wang[14] and He et al[15] found that BBTD was effective for the treatment of hyperlipidemia, however, there is a lack of systematic review and meta-analysis regarding its efficacy and safety in the treatment of HL. Here, COG2 is linked to hyperlipidemia.