According to the World Healthy Organization classification, patients with the specific recurrent cytogenetic abnormality of t(8;21)(q22;q22), should be diagnosed with AML regardless of the blast count.[6] In the majority of cases, the RUNX1–RUNX1T1 fusion gene is the result of balanced translocation chromosomes 8 and 21.[7] But there are some complex variant forms of translocations. The gene discussed is RUNX1; the disease is acute myeloid leukemia.