Some studies suggest that most symptoms of MetS are associated with an increased production of C-reactive protein (CRP) and pro-inflammatory cytokines (PICs) ― especially interferon gamma (IFNγ) and tumor necrosis factor-alpha (TNFα) ― as well as a higher incidence of highly productive alleles of genes contributing to PICs production [4]. The gene discussed is CRP; the disease is metabolic syndrome.