APP and Alzheimer disease: To this end, Guo et al. [29] reported that treatment of APP/PS1 Tg mice for 3 months with Fe concurrently increased the expression of β -secretase 1 (BACE-1) and Presenilin 1 (PS1) and decreased the expression of a disintegrin and metallopeptidase domain 10 (ADAM-10), resulting in the production of Aβ during the course of AD development and progression.