NOS3 and coronary artery disorder: p.Glu298Asp lowers eNOS activity by disruption of eNOS caveolar localization.11 Another variant, rs3918226, which is situated in the NOS3 promoter and was found to lower promoter activity,12 has been shown to associate with both hypertension12 and coronary artery disease.13 rs3918226 is in low LD (r2 = 0.17) with our lead SNP and did not reach genome‐wide significance for association with AS or AIS.