We analyzed preoperative clinical parameters to predict AP associated with oncologic prognosis using univariate and multivariate logistic regression analyses, and found that preoperative PSA (odds ratio [OR] 1.270, p < 0.001), biopsy GS (GS 7 vs. GS 6: OR 4.353, p = 0.001; and GS ≥8 vs. GS 6: OR 28.076, p < 0.001) were independent prognostic factors for AP (Table 3). This evidence concerns the gene KLK3 and alkaline phosphatase measurement.