MTDH and migraine disorder: We have previously replicated the finding of an association for two of the established risk alleles for migraine in a Swedish migraine case-control population, rs2651899 in PRDM16 (PR/SET domain 16) and rs1835740 located between MTDH (metadherin) and PGCP (carboxypeptidase Q) on chromosome 8q22.1 [26].