LincRNA AK006025 was involved in regulating Nef-induced CXCL9, CXCL10, and CXCL11 expression through interaction with NF-κB p65 and CBP/P300, which may play key roles in neuroinflammation and pathogenesis of HAND. Here, NFKB1 is linked to HIV-associated neurocognitive disorder.