Furthermore, an investigation concerning effects of ZJW on eight kinds of human cancer cell lines suggested that ZJW has significant anti-cancer activities due to up-regulation of pro-apoptosis proteins (caspase-3, caspase-9, Bax and Bak) and down-regulation of anti- apoptosis proteins (Bcl-2 and Bcl-xl) [100]. Here, BAK1 is linked to cancer.