Ever since the discovery that prostate cancer (PCa) growth after androgen deprivation therapy (ADT) remains dependent on androgen receptor (AR) signaling, researchers have been looking for new effective ways to block the action of this hormone-dependent transcription factor (Attard et al. 2009, Tran et al. 2009, Scher et al. 2012). Here, AR is linked to posterior cortical atrophy.