AR and neoplasm: Due to great similarities in the mechanism of action between nuclear receptors, GR is suggested to take over the role of AR by driving the expression of a subset of androgen-responsive genes, thus enabling the tumor to progress even in presence of the AR-selective antagonist enzalutamide (Arora et al. 2013, Kach et al. 2015, Li et al. 2017, Shah et al. 2017, Puhr et al. 2018).