STIM1 and muscular disease: 2012) that regulates various cellular functions such as gene expression, cell motility and muscle contraction (Berridge et al. 2003; Clapham, 2007; Stiber et al. 2008). The ER Ca2+ sensor STIM1 translocates to the PM to bind and gate ORAI channels following store depletion (Liou et al. 2005; Roos et al. 2005; Zhang et al. 2005), and mutations in STIM1 or ORAI1 genes lead to severe immunological or muscular diseases (Feske, 2009; Bohm et al. 2013; Hedberg et al. 2014; Misceo et al. 2014; Morin et al. 2014; Nesin et al. 2014; Endo et al. 2015; Walter et al. 2015; Bohm et al. 2017).