The subsequent Gene Ontology analysis identified the following processes: chromatin remodeling, telomere organization, chromosome segregation and cell cycle checkpoint as dependent on BRM and downregulated in ACC (Fig. 7, Supplementary Table 1 Sub-table 3 and 4) suggesting that BRM acts mostly as transcriptional repressor in ACC cells. This evidence concerns the gene SMARCA2 and adrenal cortex carcinoma.