PLP1 and Pelizeaus-Merzbacher spectrum disorder: Further, clinical studies link MS to the expression of metabolic stress-inducing mutant isoforms of PLP1, either through misdiagnosis of Pelizaeus-Merzbacher disease as MS, or by demonstrating somatic RNA editing of PLP1 mRNA (and the encoded mutant protein) in demyelinating lesions from MS patients7,31,87.