CD274 and cancer: V-domain Ig suppressor of T cell activation (VISTA), which is also known as C10orf54, differentiation of ESC-1 (Dies1), DD1α, platelet receptor Gi24 precursor, and PD-1 homolog (PD-1H), is a member of the B7-family that shares significant homology with PD-L1 and PD-L2.19–23 Human and murine VISTA proteins are predominantly expressed on haematopoietic cells and myeloid cells, as well as being weakly expressed on T cells.24 Although VISTA is present in non-cancer cells at tumour sites, its expression in tumour cells, including gynaecologic malignancies, has not yet been examined.